Dataset Information

Homogeneous self-aligned liquid crystals on wrinkled-wall poly(dimethylsiloxane) via localised ion-beam irradiation.

ABSTRACT: We demonstrate self-aligned liquid crystals (LCs) using a wrinkled-wall polydimethylsiloxane (PDMS) wrinkle structure, which is a key factor to obtain a stable homogeneous alignment state with positive LCs. We constructed the wrinkled walls via localised surface exposure to IB radiation, which passed through a long length localised pattern mask. The creation of the wrinkled wall helped to align the LC molecules homogeneously because the wrinkled wall acted as a guide for the arrangement of positive LC molecules. In addition, we confirmed the stability of the alignment state as the width of the wrinkled wall was changed. Although this wrinkled-wall method is a non-contact method, LC alignment is achieved via an anisotropic topographical guide, which provides the LC molecules with stable homogeneous alignment.

SUBMITTER: Jeong HC

PROVIDER: S-EPMC4345327 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Homogeneous self-aligned liquid crystals on wrinkled-wall poly(dimethylsiloxane) via localised ion-beam irradiation.

Jeong Hae-Chang HC Park Hong-Gyu HG Lee Ju Hwan JH Jung Yoon Ho YH Jang Sang Bok SB Seo Dae-Shik DS

Scientific reports 20150302

We demonstrate self-aligned liquid crystals (LCs) using a wrinkled-wall polydimethylsiloxane (PDMS) wrinkle structure, which is a key factor to obtain a stable homogeneous alignment state with positive LCs. We constructed the wrinkled walls via localised surface exposure to IB radiation, which passed through a long length localised pattern mask. The creation of the wrinkled wall helped to align the LC molecules homogeneously because the wrinkled wall acted as a guide for the arrangement of posit ...[more]

PMID: 25728372

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Project description:Growth factors have been shown to be potent mediators of osteogenesis. However, their use in tissue-engineered scaffolds not only can be costly but also can induce undesired responses in surrounding tissues. Thus, the ability to specifically induce osteogenic differentiation in the absence of exogenous growth factors through manipulation of scaffold material properties would be desirable for bone regeneration. Previous research indicates that addition of inorganic or hydrophobic components to organic, hydrophilic scaffolds can enhance multipotent stem cell (MSC) osteogenesis. However, the combined impact of scaffold inorganic content and hydrophobicity on MSC behavior has not been systematically explored, particularly in three-dimensional (3D) culture systems. The aim of the present study was therefore to examine the effects of simultaneous increases in scaffold hydrophobicity and inorganic content on MSC osteogenic fate decisions in a 3D culture environment toward the development of intrinsically osteoinductive scaffolds. Mouse 10T½ MSCs were encapsulated in a series of novel scaffolds composed of varying levels of hydrophobic, inorganic poly(dimethylsiloxane) (PDMS) and hydrophilic, organic poly(ethylene glycol) (PEG). After 21 days of culture, increased levels of osteoblast markers, runx2 and osteocalcin, were observed in scaffolds with increased PDMS content. Bone extracellular matrix (ECM) molecules, collagen I and calcium phosphate, were also elevated in formulations with higher PDMS:PEG ratios. Importantly, this osteogenic response appeared to be specific in that markers for chondrocytic, smooth muscle cell, and adipocytic lineages were not similarly affected by variations in scaffold PDMS content. As anticipated, the increase in scaffold hydrophobicity accompanying increasing PDMS levels was associated with elevated scaffold serum protein adsorption. Thus, scaffold inorganic content combined with alterations in adsorbed serum proteins may underlie the observed cell behavior.

Dataset Information

Homogeneous self-aligned liquid crystals on wrinkled-wall poly(dimethylsiloxane) via localised ion-beam irradiation.

Publications

Homogeneous self-aligned liquid crystals on wrinkled-wall poly(dimethylsiloxane) via localised ion-beam irradiation.

Similar Datasets

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