Ontology highlight
ABSTRACT:
SUBMITTER: Deng J
PROVIDER: S-EPMC4345580 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Deng Junjing J Vine David J DJ Chen Si S Nashed Youssef S G YS Jin Qiaoling Q Phillips Nicholas W NW Peterka Tom T Ross Rob R Vogt Stefan S Jacobsen Chris J CJ
Proceedings of the National Academy of Sciences of the United States of America 20150209 8
Trace metals play important roles in normal and in disease-causing biological functions. X-ray fluorescence microscopy reveals trace elements with no dependence on binding affinities (unlike with visible light fluorophores) and with improved sensitivity relative to electron probes. However, X-ray fluorescence is not very sensitive for showing the light elements that comprise the majority of cellular material. Here we show that X-ray ptychography can be combined with fluorescence to image both ce ...[more]