Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
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ABSTRACT:
SUBMITTER: Deranieh RM
PROVIDER: S-EPMC4346228 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
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Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
Deranieh Rania M RM Greenberg Miriam L ML Le Calvez Pierre-B PB Mooney Maura C MC Migaud Marie E ME
Organic & biomolecular chemistry 20121107 48
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode. ...[more]
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