The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer.
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ABSTRACT:
SUBMITTER: Stojkovic V
PROVIDER: S-EPMC4346287 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
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The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer.
Stojković Vanja V Perissinotti Laura L LL Lee Jeeyeon J Benkovic Stephen J SJ Kohen Amnon A
Chemical communications (Cambridge, England) 20101025 47
Comparison of the nature of hydride transfer in wild-type and active site mutant (I14A) of dihydrofolate reductase suggests that the size of this side chain at position 14 modulates H-tunneling. ...[more]
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