Ontology highlight
ABSTRACT:
SUBMITTER: Tian H
PROVIDER: S-EPMC4346425 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Tian Huilai H Davidowitz Eliot E Lopez Patricia P He Ping P Schulz Philip P Moe James J Sierks Michael R MR
Neurobiology of aging 20141211 3
Oligomeric tau species are important in the onset and progression of Alzheimer's disease (AD), as they are neurotoxic and can propagate tau-tangle pathology. Therefore, reagents that selectively recognize different key morphologies of tau are needed to help define the role of tau in AD and related diseases. We utilized a biopanning protocol that combines the binding diversity of phage-displayed antibody libraries with the powerful imaging capability of atomic force microscopy to isolate single-c ...[more]