Ontology highlight
ABSTRACT:
SUBMITTER: Weekers L
PROVIDER: S-EPMC4346530 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Weekers Laurent L de Tullio Pascal P Bovy Christophe C Poma Laurence L Marée Raphaël R Bonvoisin Catherine C Defraigne Jean-Olivier JO Krzesinski Jean-Marie JM Jouret François F
American journal of translational research 20150119 1
Activation of the calcium-sensing receptor (CaSR) by ischemia/reperfusion (I/R) favours apoptosis in cardiomyocytes, hepatocytes and neurons. Its role in renal I/R is unknown. We investigated the impact of pharmacological preactivation of the CaSR on kidney structure and function in a murine model of bilateral renal 30-min ischemia and 48-hour reperfusion, and in a 6-year cohort of kidney transplant recipients (KTR). C57BL/6J mice were administered daily with CaSR agonist, R-568, or with vehicle ...[more]