Ontology highlight
ABSTRACT:
SUBMITTER: Roland WS
PROVIDER: S-EPMC4346584 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Roland Wibke S U WS Sanders Marijn P A MP van Buren Leo L Gouka Robin J RJ Gruppen Harry H Vincken Jean-Paul JP Ritschel Tina T
PloS one 20150302 3
The human bitter taste receptor hTAS2R39 can be activated by many dietary (iso)flavonoids. Furthermore, hTAS2R39 activity can be blocked by 6-methoxyflavanones, 4'-fluoro-6-methoxyflavanone in particular. A structure-based pharmacophore model of the hTAS2R39 binding pocket was built using Snooker software, which has been used successfully before for drug design of GPCRs of the rhodopsin subfamily. For the validation of the model, two sets of compounds, both of which contained actives and inactiv ...[more]