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Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb Folium eriobotryae.

ABSTRACT: Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA that are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway, the rheumatoid arthritis pathway and NF-?B signaling pathway. All these demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations.

SUBMITTER: Zhang J

PROVIDER: S-EPMC4346873 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb Folium eriobotryae.

Zhang Jingxiao J Li Yan Y Chen Su-Shing SS Zhang Lilei L Wang Jinghui J Yang Yinfeng Y Zhang Shuwei S Pan Yanqiu Y Wang Yonghua Y Yang Ling L

International journal of molecular sciences 20150128 2

Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb F ...[more]

PMID: 25636035

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Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb Folium eriobotryae.

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Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb Folium eriobotryae.

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