Ontology highlight
ABSTRACT:
SUBMITTER: Yang CS
PROVIDER: S-EPMC4347017 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Yang Chul-Su CS Kim Jwa-Jin JJ Kim Tae Sung TS Lee Phil Young PY Kim Soo Yeon SY Lee Hye-Mi HM Shin Dong-Min DM Nguyen Loi T LT Lee Moo-Seung MS Jin Hyo Sun HS Kim Kwang-Kyu KK Lee Chul-Ho CH Kim Myung Hee MH Park Sung Goo SG Kim Jin-Man JM Choi Hueng-Sik HS Jo Eun-Kyeong EK
Nature communications 20150206
Excessive activation of the NLRP3 inflammasome results in damaging inflammation, yet the regulators of this process remain poorly defined. Herein, we show that the orphan nuclear receptor small heterodimer partner (SHP) is a negative regulator of NLRP3 inflammasome activation. NLRP3 inflammasome activation leads to an interaction between SHP and NLRP3, proteins that are both recruited to mitochondria. Overexpression of SHP competitively inhibits binding of NLRP3 to apoptosis-associated speck-lik ...[more]