Ontology highlight
ABSTRACT:
SUBMITTER: Wan H
PROVIDER: S-EPMC4347215 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Nature communications 20150210
A(H1N1)pdm09 influenza A viruses predominated in the 2013-2014 USA influenza season, and although most of these viruses remain sensitive to Food and Drug Administration-approved neuraminidase (NA) inhibitors, alternative therapies are needed. Here we show that monoclonal antibody CD6, selected for binding to the NA of the prototypic A(H1N1)pdm09 virus, A/California/07/2009, protects mice against lethal virus challenge. The crystal structure of NA in complex with CD6 Fab reveals a unique epitope, ...[more]