Ontology highlight
ABSTRACT:
SUBMITTER: Grigore AD
PROVIDER: S-EPMC4347593 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Grigore Alexandru Dan AD Ben-Jacob Eshel E Farach-Carson Mary C MC
Frontiers in oncology 20150303
Neuroendocrine differentiation (NED) marks a structural and functional feature of certain cancers, including prostate cancer (PCa), whereby the malignant tissue contains a significant proportion of cells displaying neuronal, endocrine, or mixed features. NED cells produce, and can secrete, a cocktail of mediators commonly encountered in the nervous system, which may stimulate and coordinate cancer growth. In PCa, NED appears during advanced stages, subsequent to treatment, and accompanies treatm ...[more]