Ontology highlight
ABSTRACT:
SUBMITTER: Viero G
PROVIDER: S-EPMC4347638 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Viero Gabriella G Lunelli Lorenzo L Passerini Andrea A Bianchini Paolo P Gilbert Robert J RJ Bernabò Paola P Tebaldi Toma T Diaspro Alberto A Pederzolli Cecilia C Quattrone Alessandro A
The Journal of cell biology 20150223 5
Translation is increasingly recognized as a central control layer of gene expression in eukaryotic cells. The overall organization of mRNA and ribosomes within polysomes, as well as the possible role of this organization in translation are poorly understood. Here we show that polysomes are primarily formed by three distinct classes of ribosome assemblies. We observe that these assemblies can be connected by naked RNA regions of the transcript. We show that the relative proportions of the three c ...[more]