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Perylene-diimide-based nanoparticles as highly efficient photoacoustic agents for deep brain tumor imaging in living mice.

ABSTRACT: In order to promote preclinical and clinical applications of photoacoustic imaging, novel photoacoustic contrast agents are highly desired for molecular imaging of diseases, especially for deep tumor imaging. Here, perylene-3,4,9,10-tetracarboxylic diiimide-based near-infrared-absorptive organic nanoparticles are reported as an efficient agent for photoacoustic imaging of deep brain tumors in living mice with enhanced permeability and retention effect.

SUBMITTER: Fan Q

PROVIDER: S-EPMC4347809 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Perylene-diimide-based nanoparticles as highly efficient photoacoustic agents for deep brain tumor imaging in living mice.

Fan Quli Q Cheng Kai K Yang Zhen Z Zhang Ruiping R Yang Min M Hu Xiang X Ma Xiaowei X Bu Lihong L Lu Xiaomei X Xiong Xiaoxing X Huang Wei W Zhao Heng H Cheng Zhen Z

Advanced materials (Deerfield Beach, Fla.) 20141106 5

In order to promote preclinical and clinical applications of photoacoustic imaging, novel photoacoustic contrast agents are highly desired for molecular imaging of diseases, especially for deep tumor imaging. Here, perylene-3,4,9,10-tetracarboxylic diiimide-based near-infrared-absorptive organic nanoparticles are reported as an efficient agent for photoacoustic imaging of deep brain tumors in living mice with enhanced permeability and retention effect. ...[more]

PMID: 25376906

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