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Vaginal type-II mucosa is an inductive site for primary CD8? T-cell mucosal immunity.

ABSTRACT: The structured lymphoid tissues are considered the only inductive sites where primary T-cell immune responses occur. The naïve T cells in structured lymphoid tissues, once being primed by antigen-bearing dendritic cells, differentiate into memory T cells and traffic back to the mucosal sites through the bloodstream. Contrary to this belief, here we show that the vaginal type-II mucosa itself, despite the lack of structured lymphoid tissues, can act as an inductive site during primary CD8(+) T-cell immune responses. We provide evidence that the vaginal mucosa supports both the local immune priming of naïve CD8(+) T cells and the local expansion of antigen-specific CD8(+) T cells, thereby demonstrating a different paradigm for primary mucosal T-cell immune induction.

SUBMITTER: Wang Y

PROVIDER: S-EPMC4348041 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Vaginal type-II mucosa is an inductive site for primary CD8⁺ T-cell mucosal immunity.

Wang Yichuan Y Sui Yongjun Y Kato Shingo S Hogg Alison E AE Steel Jason C JC Morris John C JC Berzofsky Jay A JA

Nature communications 20150120

The structured lymphoid tissues are considered the only inductive sites where primary T-cell immune responses occur. The naïve T cells in structured lymphoid tissues, once being primed by antigen-bearing dendritic cells, differentiate into memory T cells and traffic back to the mucosal sites through the bloodstream. Contrary to this belief, here we show that the vaginal type-II mucosa itself, despite the lack of structured lymphoid tissues, can act as an inductive site during primary CD8(+) T-ce ...[more]

PMID: 25600442

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