Ontology highlight
ABSTRACT:
SUBMITTER: DeBosch BJ
PROVIDER: S-EPMC4348061 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Nature communications 20140807
Excess circulating uric acid, a product of hepatic glycolysis and purine metabolism, often accompanies metabolic syndrome. However, whether hyperuricaemia contributes to the development of metabolic syndrome or is merely a by-product of other processes that cause this disorder has not been resolved. In addition, how uric acid is cleared from the circulation is incompletely understood. Here we present a genetic model of spontaneous, early-onset metabolic syndrome in mice lacking the enterocyte ur ...[more]