Ontology highlight
ABSTRACT:
SUBMITTER: Iyer MR
PROVIDER: S-EPMC4348089 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20150113
Racemic N-substituted -1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols containing cis-4a-aralkyl groups were explored as probes for opioid receptors. Specifically cis-4a-phenylpropyl, -phenylbutyl, and-phenylpentyl groups coupled with widely varied substituents on the nitrogen atom were synthesized and their pharmacological profiles at opioid receptors examined. The study yielded compounds with good affinity and moderate to potent antagonist activity at the μ- and δ-opioid receptors, and ag ...[more]