Ontology highlight
ABSTRACT:
SUBMITTER: Nair V
PROVIDER: S-EPMC4348211 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Nair Vasu V Okello Maurice O MO Mangu Naveen K NK Seo Byung I BI Gund Machhindra G MG
Bioorganic & medicinal chemistry letters 20150128 6
Multi-drug resistant tuberculosis (MDR-TB) is emerging as a serious global health problem, which has been elevated through co-infection involving HIV and MDR-Mtb. The discovery of new compounds with anti-MDR TB efficacy and favorable metabolism profiles is an important scientific challenge. Using computational biology and ligand docking data, we have conceived a multifunctional molecule, 2, as a potential anti-MDR TB agent. This compound was produced through a multi-step synthesis. It exhibited ...[more]