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Genomic characterization of two novel HIV-1 second-generation recombinant forms among men who have sex with men in Beijing, China.


ABSTRACT: We report two different unique HIV-1 recombinant viruses from two HIV-positive men who have sex with men (MSM) in Beijing, China. Phylogenetic analysis of near full-length genomes (NFLG) showed that the unique recombinant forms (URFs) were comprised of gene regions from two circulating recombinant forms, CRF01_AE and CRF07_BC, both common in China. The parental CRF01_AE region of the recombinants clustered together with a previously described cluster 4 lineage of CRF01_AE. The CRF07_BC regions of both the recombinants clustered within the CRF07_BC radiation, but were distinct from other CRF07_BC reference sequences. The two recombinant forms had two breakpoints in common. The emergence of the two URFs indicates the ongoing generation of recombinant viruses involving CRF01_AE and CRF07_BC, and may provide insight into our understanding of the dynamics and complexity of the HIV-1 epidemic in China.

SUBMITTER: Li Z 

PROVIDER: S-EPMC4348344 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Genomic characterization of two novel HIV-1 second-generation recombinant forms among men who have sex with men in Beijing, China.

Li Zheng Z   Wei Huamian H   Feng Yi Y   Li Jia J   Kalish Marcia L ML   Lu Hongyan H   Yin Lu L   Liao Lingjie L   Qian Han-Zhu HZ   Frost Simon D W SD   Ruan Yuhua Y   Vermund Sten H SH   Shao Yiming Y   Xing Hui H  

AIDS research and human retroviruses 20150108 3


We report two different unique HIV-1 recombinant viruses from two HIV-positive men who have sex with men (MSM) in Beijing, China. Phylogenetic analysis of near full-length genomes (NFLG) showed that the unique recombinant forms (URFs) were comprised of gene regions from two circulating recombinant forms, CRF01_AE and CRF07_BC, both common in China. The parental CRF01_AE region of the recombinants clustered together with a previously described cluster 4 lineage of CRF01_AE. The CRF07_BC regions o  ...[more]

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