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Short communication: Emergence of novel A/G recombinant HIV-1 strains in Argentina.

ABSTRACT: The predominant circulating HIV-1 strains in South America are subtype B and B/F recombinants with different distributions among countries. However, the emergence of other subtypes is a matter of concern and needs continuous monitoring. We identified three different A/G recombinants in Argentina, two of them in vertically infected children from unlinked mothers and one in an adult female. HIV-1 pol sequences from the children showed novel A/G recombination patterns and no phylogenetic relationship with previously reported South American A/G sequences. The third A/G recombinant was a CRF06_cpx with African origin. The detection of new or unusual subtypes is important to avoid false-negative PCR HIV-1 early diagnosis due to detection failures and for future vaccine development.

SUBMITTER: Fernandez MF

PROVIDER: S-EPMC4348371 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Short communication: Emergence of novel A/G recombinant HIV-1 strains in Argentina.

Fernández María F MF Golemba Marcelo D MD Terrones Carmen C Paradiso Patricia P Nassif Juan C JC Bologna Rosa R Mangano Andrea A Sen Luisa L Aulicino Paula C PC

AIDS research and human retroviruses 20141222 3

The predominant circulating HIV-1 strains in South America are subtype B and B/F recombinants with different distributions among countries. However, the emergence of other subtypes is a matter of concern and needs continuous monitoring. We identified three different A/G recombinants in Argentina, two of them in vertically infected children from unlinked mothers and one in an adult female. HIV-1 pol sequences from the children showed novel A/G recombination patterns and no phylogenetic relationsh ...[more]

PMID: 25417788

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