Ontology highlight
ABSTRACT:
SUBMITTER: Ong S
PROVIDER: S-EPMC4348473 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Ong SuFey S Ligons Davinna L DL Barin Jobert G JG Wu Lei L Talor Monica V MV Diny Nicola N Fontes Jillian A JA Gebremariam Elizabeth E Kass David A DA Rose Noel R NR Čiháková Daniela D
The American journal of pathology 20150123 3
Myocarditis is a leading cause of sudden cardiac failure in young adults. Natural killer (NK) cells, a subset of the innate lymphoid cell compartment, are protective in viral myocarditis. Herein, we demonstrated that these protective qualities extend to suppressing autoimmune inflammation. Experimental autoimmune myocarditis (EAM) was initiated in BALB/c mice by immunization with myocarditogenic peptide. During EAM, activated cardiac NK cells secreted interferon γ, perforin, and granzyme B, and ...[more]