Ontology highlight
ABSTRACT:
SUBMITTER: McGreevy JW
PROVIDER: S-EPMC4348559 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Disease models & mechanisms 20150301 3
Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly promising therapeutic strategy is to replace or repair the defective dystrophin gene by gene therapy. Numerous animal models of DMD have been developed over the last 30 years, ranging from invertebrate to large mammalian models. mdx mice are the most commonly employed models in DMD research and have been used to lay t ...[more]