Ontology highlight
ABSTRACT:
SUBMITTER: Lu M
PROVIDER: S-EPMC4348640 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Lü Mingrong M Ding Keshuo K Zhang Guofeng G Yin Mianmian M Yao Guidong G Tian Hui H Lian Jie J Liu Lin L Liang Meng M Zhu Tao T Sun Fei F
Scientific reports 20150304
Tamoxifen represents a major adjuvant therapy to those patients with estrogen receptor-alpha positive breast cancer. However, tamoxifen resistance occurs quite often, either de novo or acquired during treatment. To investigate the role of miR-320a in the development of resistance to tamoxifen, we established tamoxifen-resistant (TamR) models by continually exposing MCF-7 or T47D breast cancer cells to tamoxifen, and identified microRNA(miRNA)-320a as a down-regulated miRNA in tamoxifen resistant ...[more]