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Urinary metals and heart rate variability: a cross-sectional study of urban adults in Wuhan, China.

ABSTRACT: Epidemiological studies have suggested an association between external estimates of exposure to metals in air particles and altered heart rate variability (HRV). However, studies on the association between internal assessments of metals exposure and HRV are limited.The purpose of this study was to examine the potential association between urinary metals and HRV among residents of an urban community in Wuhan, China.We performed a cross-sectional analysis of 23 urinary metals and 5-min HRV indices (SDNN, standard deviation of normal-to-normal intervals; r-MSSD, root mean square of successive differences in adjacent normal-to-normal intervals; LF, low frequency; HF, high frequency; TP, total power) using baseline data on 2,004 adult residents of Wuhan.After adjusting for other metals, creatinine, and other covariates, natural log-transformed urine titanium concentration was positively associated with all HRV indices (all p < 0.05). Moreover, we estimated negative associations between cadmium and r-MSSD, LF, HF, and TP; between lead and r-MSSD, HF, and TP; and between iron, copper, and arsenic and HF, SDNN, and LF, respectively, based on models adjusted for other metals, creatinine, and covariates (all p < 0.10). Several associations differed according to cardiovascular disease risk factors. For example, negative associations between cadmium and r-MSSD were stronger among participants ? 52 years of age (vs. > 52), current smokers (vs. nonsmokers), body mass index < 25 kg/m2 (vs. ? 25), and among those who were not hypertensive.Urine concentrations of several metals were associated with HRV parameters in our cross-sectional study population. These findings need replication in other studies with adequate sample sizes.

SUBMITTER: Feng W

PROVIDER: S-EPMC4348740 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Urinary metals and heart rate variability: a cross-sectional study of urban adults in Wuhan, China.

Feng Wei W He Xiaosheng X Chen Mu M Deng Siyun S Qiu Gaokun G Li Xiaoliang X Liu Chuanyao C Li Jun J Deng Qifei Q Huang Suli S Wang Tian T Dai Xiayun X Yang Binyao B Yuan Jing J He Meian M Zhang Xiaomin X Chen Weihong W Kan Haidong H Wu Tangchun T

Environmental health perspectives 20141030 3

<h4>Background</h4>Epidemiological studies have suggested an association between external estimates of exposure to metals in air particles and altered heart rate variability (HRV). However, studies on the association between internal assessments of metals exposure and HRV are limited.<h4>Objectives</h4>The purpose of this study was to examine the potential association between urinary metals and HRV among residents of an urban community in Wuhan, China.<h4>Methods</h4>We performed a cross-section ...[more]

PMID: 25356836

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Project description:Background Vitamin E is an essential nutrient in human body famous for its antioxidant and non-antioxidant functions. However, little is known about vitamin E deficiency status in urban adults of Wuhan from central China. Our aim is to describe the distribution of both circulating and lipid-adjusted serum vitamin E concentration in urban adults of Wuhan. Methods We hypothesized that the prevalence rate of vitamin E deficiency would be low in Wuhan in consideration of the Chinese food composition. A cross-sectional study with 846 adults was performed in a single-center. Concentrations of vitamin E were measured by liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS). Results The median (interquartile range, IQR) of serum vitamin E concentration was 27.40 (22.89–33.20) μmol/L while that of serum vitamin E concentration adjusted by total cholesterol or the sum of cholesterol (TC) and triglyceride (TG) (the sum of cholesterol and triglyceride, TLs) were 6.20 (5.30–7.48) and 4.86 (4.10–5.65) mmol/mol, respectively. No significant difference of the circulating and TC-adjusted vitamin E concentration was found between male and female except for vitamin E/TLs. However, concentrations of vitamin E increased significantly (r = 0.137, P < 0.001) with age, but lipid-adjusted concentrations of vitamin E did not. On analysis of risk factors, the subjects characterized by hypercholesterolemia are more likely to exhibit higher circulating but lower lipid-adjusted vitamin E level due to adequacy of the serum carriers for delivery of vitamin E. Only 0.47% of the population were below 12 μmol/L of vitamin E defined as functional deficiency. Conclusion The prevalence rate of vitamin E deficiency in urban adults of Wuhan is low, which is important and useful to clinicians for clinical decision-making in public health practice. Supplementary Information The online version contains supplementary material available at 10.1186/s40001-023-01103-9.

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Urinary metals and heart rate variability: a cross-sectional study of urban adults in Wuhan, China.

Publications

Urinary metals and heart rate variability: a cross-sectional study of urban adults in Wuhan, China.

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