Ontology highlight
ABSTRACT:
SUBMITTER: Schwarz LJ
PROVIDER: S-EPMC4348968 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Schwarz Luis J LJ Fox Emily M EM Balko Justin M JM Garrett Joan T JT Kuba María Gabriela MG Estrada Mónica Valeria MV González-Angulo Ana María AM Mills Gordon B GB Red-Brewer Monica M Mayer Ingrid A IA Abramson Vandana V Rizzo Monica M Kelley Mark C MC Meszoely Ingrid M IM Arteaga Carlos L CL
The Journal of clinical investigation 20141117 12
Estrogen receptor-positive (ER(+)) breast cancers adapt to hormone deprivation and become resistant to antiestrogen therapy. Here, we performed deep sequencing on ER(+) tumors that remained highly proliferative after treatment with the aromatase inhibitor letrozole and identified a D189Y mutation in the inhibitory SH2 domain of the SRC family kinase (SFK) LYN. Evaluation of 463 breast tumors in The Cancer Genome Atlas revealed four LYN mutations, two of which affected the SH2 domain. In addition ...[more]