Ontology highlight
ABSTRACT:
SUBMITTER: Kia R
PROVIDER: S-EPMC4349141 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Kia Richard R Kelly Lorna L Sison-Young Rowena L C RL Zhang Fang F Pridgeon Chris S CS Heslop James A JA Metcalfe Pete P Kitteringham Neil R NR Baxter Melissa M Harrison Sean S Hanley Neil A NA Burke Zoë D ZD Storm Mike P MP Welham Melanie J MJ Tosh David D Küppers-Munther Barbara B Edsbagge Josefina J Starkey Lewis Philip J PJ Bonner Frank F Harpur Ernie E Sidaway James J Bowes Joanne J Fenwick Stephen W SW Malik Hassan H Goldring Chris E P CE Park B Kevin BK
Toxicological sciences : an official journal of the Society of Toxicology 20141218 1
Emerging hepatic models for the study of drug-induced toxicity include pluripotent stem cell-derived hepatocyte-like cells (HLCs) and complex hepatocyte-non-parenchymal cellular coculture to mimic the complex multicellular interactions that recapitulate the niche environment in the human liver. However, a specific marker of hepatocyte perturbation, required to discriminate hepatocyte damage from non-specific cellular toxicity contributed by non-hepatocyte cell types or immature differentiated ce ...[more]