Novel ALK inhibitors in clinical use and development.
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ABSTRACT:
SUBMITTER: Iragavarapu C
PROVIDER: S-EPMC4349797 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Novel ALK inhibitors in clinical use and development.
Iragavarapu Chaitanya C Mustafa Milaim M Akinleye Akintunde A Furqan Muhammad M Mittal Varun V Cang Shundong S Liu Delong D
Journal of hematology & oncology 20150227
Anaplastic lymphoma kinase 1 (ALK-1) is a member of the insulin receptor tyrosine kinase family. ALK-1 was initially found in anaplastic large cell lymphoma (ALCL). ALK mutations have also been implicated in the pathogenesis of non-small cell lung cancer (NSCLC) and other solid tumors. Multiple small molecule inhibitors with activity against ALK and related oncoproteins are under clinical development. Two of them, crizotinib and ceritinib, have been approved by FDA for treatment of locally advan ...[more]
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