Ontology highlight
ABSTRACT:
SUBMITTER: Hart JR
PROVIDER: S-EPMC4350361 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Oncotarget 20141201 24
Using RNA-seq (RNA sequencing) of ribosome-depleted RNA, we have identified 1,273 lncRNAs (long non-coding RNAs) in P493-6 human B-cells. Of these, 534 are either up- or downregulated in response to MYC overexpression. An increase in MYC occupancy near their TSS (transcription start sites) was observed for MYC-responsive lncRNAs suggesting these are direct MYC targets. MYC binds to the same TSS across several cell lines, but the number of TSS bound depends on cellular MYC levels and increases wi ...[more]