Ontology highlight
ABSTRACT:
SUBMITTER: Montagne A
PROVIDER: S-EPMC4350773 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Neuron 20150101 2
The blood-brain barrier (BBB) limits entry of blood-derived products, pathogens, and cells into the brain that is essential for normal neuronal functioning and information processing. Post-mortem tissue analysis indicates BBB damage in Alzheimer's disease (AD). The timing of BBB breakdown remains, however, elusive. Using an advanced dynamic contrast-enhanced MRI protocol with high spatial and temporal resolutions to quantify regional BBB permeability in the living human brain, we show an age-dep ...[more]