The -844 G>A PAI-1 polymorphism is associated with acute coronary syndrome in Mexican population.

ABSTRACT:

Background

Acute coronary syndrome (ACS) has an important impact in public health with high morbidity and mortality. Prothrombotic and proinflammatory states are involved in the pathogenesis of the disease. Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of the fibrinolysis and also is part of immune response. The -844 G>A gene polymorphism is related to increased PAI-1 protein levels. The aim of the study is to evaluate the association of -844 G>A PAI-1 polymorphism with ACS.

Methods

A total of 646 individuals were recruited from Western Mexico: 350 unrelated healthy subjects and 296 patients with diagnosis of ACS.

Results

The most important risk factor in our population was hypertension, followed by smoking. The genetic distribution showed an associ

SUBMITTER: Garcia-Gonzalez IJ 

PROVIDER: S-EPMC4350946 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature