Dataset Information

Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.

ABSTRACT: We discovered a lethal hemorrhagic syndrome arising from severe thrombocytopenia in Japanese macaques kept at the Primate Research Institute, Kyoto University. Extensive investigation identified that simian retrovirus type 4 (SRV-4) was the causative agent of the disease. SRV-4 had previously been isolated only from cynomolgus macaques in which it is usually asymptomatic. We consider that the SRV-4 crossed the so-called species barrier between cynomolgus and Japanese macaques, leading to extremely severe acute symptoms in the latter. Infectious agents that cross the species barrier occasionally amplify in virulence, which is not observed in the original hosts. In such cases, the new hosts are usually distantly related to the original hosts. However, Japanese macaques are closely related to cynomolgus macaques, and can even hybridize when given the opportunity. This lethal outbreak of a novel pathogen in Japanese macaques highlights the need to modify our expectations about virulence with regards crossing species barriers.

SUBMITTER: Okamoto M

PROVIDER: S-EPMC4351523 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.

Okamoto Munehiro M Miyazawa Takayuki T Morikawa Shigeru S Ono Fumiko F Nakamura Shota S Sato Eiji E Yoshida Tomoyuki T Yoshikawa Rokusuke R Sakai Kouji K Mizutani Tetsuya T Nagata Noriyo N Takano Jun-ichiro J Okabayashi Sachi S Hamano Masataka M Fujimoto Koji K Nakaya Takaaki T Iida Tetsuya T Horii Toshihiro T Miyabe-Nishiwaki Takako T Watanabe Akino A Kaneko Akihisa A Saito Akatsuki A Matsui Atsushi A Hayakawa Toshiyuki T Suzuki Juri J Akari Hirofumi H Matsuzawa Tetsuro T Hirai Hirohisa H

Scientific reports 20150306

We discovered a lethal hemorrhagic syndrome arising from severe thrombocytopenia in Japanese macaques kept at the Primate Research Institute, Kyoto University. Extensive investigation identified that simian retrovirus type 4 (SRV-4) was the causative agent of the disease. SRV-4 had previously been isolated only from cynomolgus macaques in which it is usually asymptomatic. We consider that the SRV-4 crossed the so-called species barrier between cynomolgus and Japanese macaques, leading to extreme ...[more]

PMID: 25743183

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Dataset Information

Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.

Publications

Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host.

Similar Datasets

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