Ontology highlight
ABSTRACT:
SUBMITTER: Sumida T
PROVIDER: S-EPMC4351572 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Sumida Tomokazu T Naito Atsuhiko T AT Nomura Seitaro S Nakagawa Akito A Higo Tomoaki T Hashimoto Akihito A Okada Katsuki K Sakai Taku T Ito Masamichi M Yamaguchi Toshihiro T Oka Toru T Akazawa Hiroshi H Lee Jong-Kook JK Minamino Tohru T Offermanns Stefan S Noda Tetsuo T Botto Marina M Kobayashi Yoshio Y Morita Hiroyuki H Manabe Ichiro I Nagai Toshio T Shiojima Ichiro I Komuro Issei I
Nature communications 20150226
Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However, the precise molecular mechanisms of arterial remodelling remain elusive. We have recently reported that complement C1q activates β-catenin signalling independent of Wnts. Here, we show a critical role of complement C1-induced activation of ...[more]