Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci.
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ABSTRACT:
SUBMITTER: Lemire M
PROVIDER: S-EPMC4351585 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci.
Lemire Mathieu M Zaidi Syed H E SH Ban Maria M Ge Bing B Aïssi Dylan D Germain Marine M Kassam Irfahan I Wang Mike M Zanke Brent W BW Gagnon France F Morange Pierre-Emmanuel PE Trégouët David-Alexandre DA Wells Philip S PS Sawcer Stephen S Gallinger Steven S Pastinen Tomi T Hudson Thomas J TJ
Nature communications 20150226
The interplay between genetic and epigenetic variation is only partially understood. One form of epigenetic variation is methylation at CpG sites, which can be measured as methylation quantitative trait loci (meQTL). Here we report that in a panel of lymphocytes from 1,748 individuals, methylation levels at 1,919 CpG sites are correlated with at least one distal (trans) single-nucleotide polymorphism (SNP) (P<3.2 × 10(-13); FDR<5%). These trans-meQTLs include 1,657 SNP-CpG pairs from different c ...[more]
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