The TMEM106B locus and TDP-43 pathology in older persons without FTLD.

ABSTRACT:

Objective

To determine the independent association of the TMEM106B variants with transactive response DNA binding protein 43 (TDP-43) pathology in older persons without frontotemporal lobar degeneration (FTLD) and to explore functional pathways that link the risk variants to the pathology, including a GRN mRNA pathway.

Methods

Data came from 544 autopsied participants without FTLD in 2 community-based studies of aging. Participants underwent uniform neuropathologic evaluations, including TDP-43 cytoplasmic inclusions. We examined the association of TMEM106B variants with a semiquantitative measure of TDP-43 pathology in a series of regression analysis. We explored potential pathways by leveraging genetic, brain DNA methylation, miRNA, and transcriptomic data collected from t

SUBMITTER: Yu L 

PROVIDER: S-EPMC4351662 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature