Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury.

ABSTRACT: There is an urgent need to develop new therapeutic approaches for the treatment of severe neurological trauma, such as stroke and spinal cord injuries. However, many drugs with potential neuropharmacological activity, such as adenosine, are inefficient upon systemic administration because of their fast metabolization and rapid clearance from the bloodstream. Here, we show that conjugation of adenosine to the lipid squalene and the subsequent formation of nanoassemblies allows prolonged circulation of this nucleoside, providing neuroprotection in mouse stroke and rat spinal cord injury models. The animals receiving systemic administration of squalenoyl adenosine nanoassemblies showed a significant improvement of their neurologic deficit score in the case of cerebral ischaemia, and an early

SUBMITTER: Gaudin A 

PROVIDER: S-EPMC4351925 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature