Ontology highlight
ABSTRACT:
SUBMITTER: Parameswaran B
PROVIDER: S-EPMC4353239 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Parameswaran Balaji B Chiang Huai-Chin HC Lu Yunzhe Y Coates Julia J Deng Chu-Xia CX Baer Richard R Lin Hui-Kuan HK Li Rong R Paull Tanya T TT Hu Yanfen Y
Cell cycle (Georgetown, Tex.) 20150101 3
The BRCA1 tumor suppressor plays an important role in homologous recombination (HR)-mediated DNA double-strand-break (DSB) repair. BRCA1 is phosphorylated by Chk2 kinase upon γ-irradiation, but the role of Chk2 phosphorylation is not understood. Here, we report that abrogation of Chk2 phosphorylation on BRCA1 delays end resection and the dispersion of BRCA1 from DSBs but does not affect the assembly of Mre11/Rad50/NBS1 (MRN) and CtIP at DSBs. Moreover, we show that BRCA1 is ubiquitinated by SCF( ...[more]