Ontology highlight
ABSTRACT:
SUBMITTER: Valencia-Morales Mdel P
PROVIDER: S-EPMC4353677 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Valencia-Morales María del Pilar Mdel P Zaina Silvio S Heyn Holger H Carmona F Javier FJ Varol Nuray N Sayols Sergi S Condom Enric E Ramírez-Ruz José J Gomez Antonio A Moran Sebastian S Lund Gertrud G Rodríguez-Ríos Dalia D López-González Gladys G Ramírez-Nava Magda M de la Rocha Carmen C Sanchez-Flores Alejandro A Esteller Manel M
BMC medical genomics 20150227
<h4>Background</h4>Atherosclerosis severity-independent alterations in DNA methylation, a reversible and highly regulated DNA modification, have been detected in aortic atheromas, thus supporting the hypothesis that epigenetic mechanisms participate in the pathogenesis of atherosclerosis. One yet unaddressed issue is whether the progression of atherosclerosis is associated with an increase in DNA methylation drift in the vascular tissue. The purpose of the study was to identify CpG methylation p ...[more]