Ontology highlight
ABSTRACT:
SUBMITTER: Hurlemann R
PROVIDER: S-EPMC4354029 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Hurlemann René R Arndt Stephan S Schlaepfer Thomas E TE Reul Juergen J Maier Wolfgang W Scheele Dirk D
Scientific reports 20150310
From an evolutionary perspective the startle eye-blink response forms an integral part of the human avoidance behavioral repertoire and is typically diminished by pleasant emotional states. In major depressive disorder (MDD) appetitive motivation is impaired, evident in a reduced interference of positive emotion with the startle response. Given the pivotal role of frontostriatal neurocircuitry in orchestrating appetitive motivation, we hypothesized that inhibitory transcranial magnetic stimulati ...[more]