Ontology highlight
ABSTRACT:
SUBMITTER: Katagiri N
PROVIDER: S-EPMC4354046 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Katagiri Naohiro N Kuroda Takao T Kishimoto Hiroyuki H Hayashi Yuki Y Kumazawa Takuya T Kimura Keiji K
Scientific reports 20150310
Various cellular stresses activate autophagy, which is involved in lysosomal degradation of cytoplasmic materials for maintaining nutrient homeostasis and eliminating harmful components. Here, we show that RNA polymerase I (Pol I) transcription inhibition induces nucleolar disruption and autophagy. Treatment with autophagy inhibitors or siRNA specific for autophagy-related (ATG) proteins inhibited autophagy but not nucleolar disruption induced by Pol I transcription inhibition, which suggested t ...[more]