Dataset Information
Human Multidrug Resistance 1 gene polymorphisms and Idiopathic Pulmonary Fibrosis.
Ontology highlight
ABSTRACT: Background
For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics.Materials and methods
We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins.Results
No evidence of association was detected.Conclusion
There are 50 known MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research.
SUBMITTER: Martinelli M
PROVIDER: S-EPMC4354072 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Human Multidrug Resistance 1 gene polymorphisms and Idiopathic Pulmonary Fibrosis.
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20150101 1
<h4>Background</h4>For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics.<h4>Materials and methods</h4>We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins.<h4>Results</h4>No evidence of association was detected.<h4>Conc ...[more]
