Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system.
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SUBMITTER: Ma J
PROVIDER: S-EPMC4354132 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
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Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system.
Ma Jiao J Tong Yu Y Yu Dan D Mao Meng M
Neural regeneration research 20120101 2
A number of studies have confirmed the existence of tissue-type plasminogen activator-independent roles of neuroserpin, a member of the serine protease inhibitor superfamily. In this review article, we aim to clarify this role. These unique roles of neuroserpin are involved in its neuroprotective effect during ischemic brain injury, its regulation of tumorigenesis, and the mediation of emotion and cognition through the inhibition of urokinase-type plasminogen activator and fibrinolysin, modifica ...[more]
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