Ontology highlight
ABSTRACT:
SUBMITTER: Lim CY
PROVIDER: S-EPMC4354152 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Nature communications 20150109
Akt2 and its downstream effectors mediate insulin-stimulated GLUT4-storage vesicle (GSV) translocation and fusion with the plasma membrane (PM). Using mass spectrometry, we identify actin-capping protein Tropomodulin 3 (Tmod3) as an Akt2-interacting partner in 3T3-L1 adipocytes. We demonstrate that Tmod3 is phosphorylated at Ser71 on insulin-stimulated Akt2 activation, and Ser71 phosphorylation is required for insulin-stimulated GLUT4 PM insertion and glucose uptake. Phosphorylated Tmod3 regulat ...[more]