Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi K
PROVIDER: S-EPMC4354363 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20150223 3
Glutamatergic systems play a critical role in cognitive functions and are known to be defective in Alzheimer's disease (AD) patients. Previous literature has indicated that glial glutamate transporter EAAT2 plays an essential role in cognitive functions and that loss of EAAT2 protein is a common phenomenon observed in AD patients and animal models. In the current study, we investigated whether restored EAAT2 protein and function could benefit cognitive functions and pathology in APPSw,Ind mice, ...[more]