Ontology highlight
ABSTRACT:
SUBMITTER: Thompson MD
PROVIDER: S-EPMC4355096 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Thompson Matthew D MD Grubbs Clinton J CJ Bode Ann M AM Reid Joel M JM McGovern Renee R Bernard Philip S PS Stijleman Inge J IJ Green Jeffrey E JE Bennett Christina C Juliana M Margaret MM Moeinpour Fariba F Steele Vernon E VE Lubet Ronald A RA
Cancer prevention research (Philadelphia, Pa.) 20150213 3
Epidemiologic studies have shown that diabetics receiving the biguanide metformin, as compared with sulfonylureas or insulin, have a lower incidence of breast cancer. Metformin increases levels of activated AMPK (AMP-activated protein kinase) and decreases circulating IGF-1; encouraging its potential use in both cancer prevention and therapeutic settings. In anticipation of clinical trials in nondiabetic women, the efficacy of metformin in nondiabetic rat and mouse mammary cancer models was eval ...[more]