Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Fernandez F
PROVIDER: S-EPMC4355169 | biostudies-literature | 2015 Mar-Apr
REPOSITORIES: biostudies-literature
Gonzalez-Fernandez Federico F Betts-Obregon Brandi B Yust Brian B Mimun Joshua J Sung Dongjin D Sardar Dhiraj D Tsin Andrew T AT
Photochemistry and photobiology 20150210 2
Retinol degrades rapidly in light into a variety of photoproducts. It is remarkable that visual cycle retinoids can evade photodegradation as they are exchanged between the photoreceptors, retinal pigment epithelium and Müller glia. Within the interphotoreceptor matrix, all-trans retinol, 11-cis retinol and retinal are bound by interphotoreceptor retinoid-binding protein (IRBP). Apart from its role in retinoid trafficking and targeting, could IRBP have a photoprotective function? HPLC was used t ...[more]