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Automated classification of usual interstitial pneumonia using regional volumetric texture analysis in high-resolution computed tomography.

ABSTRACT: OBJECTIVES:We propose a novel computational approach for the automated classification of classic versus atypical usual interstitial pneumonia (UIP). MATERIALS AND METHODS:Thirty-three patients with UIP were enrolled in this study. They were classified as classic versus atypical UIP by a consensus of 2 thoracic radiologists with more than 15 years of experience using the American Thoracic Society evidence-based guidelines for computed tomography diagnosis of UIP. Two cardiothoracic fellows with 1 year of subspecialty training provided independent readings. The system is based on regional characterization of the morphological tissue properties of lung using volumetric texture analysis of multiple-detector computed tomography images. A simple digital atlas with 36 lung subregions is used to locate texture properties, from which the responses of multidirectional Riesz wavelets are obtained. Machine learning is used to aggregate and to map the regional texture attributes to a simple score that can be used to stratify patients with UIP into classic and atypical subtypes. RESULTS:We compared the predictions on the basis of regional volumetric texture analysis with the ground truth established by expert consensus. The area under the receiver operating characteristic curve of the proposed score was estimated to be 0.81 using a leave-one-patient-out cross-validation, with high specificity for classic UIP. The performance of our automated method was found to be similar to that of the 2 fellows and to the agreement between experienced chest radiologists reported in the literature. However, the errors of our method and the fellows occurred on different cases, which suggests that combining human and computerized evaluations may be synergistic. CONCLUSIONS:Our results are encouraging and suggest that an automated system may be useful in routine clinical practice as a diagnostic aid for identifying patients with complex lung disease such as classic UIP, obviating the need for invasive surgical lung biopsy and its associated risks.

SUBMITTER: Depeursinge A

PROVIDER: S-EPMC4355184 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Automated classification of usual interstitial pneumonia using regional volumetric texture analysis in high-resolution computed tomography.

Depeursinge Adrien A Chin Anne S AS Leung Ann N AN Terrone Donato D Bristow Michael M Rosen Glenn G Rubin Daniel L DL

Investigative radiology 20150401 4

<h4>Objectives</h4>We propose a novel computational approach for the automated classification of classic versus atypical usual interstitial pneumonia (UIP).<h4>Materials and methods</h4>Thirty-three patients with UIP were enrolled in this study. They were classified as classic versus atypical UIP by a consensus of 2 thoracic radiologists with more than 15 years of experience using the American Thoracic Society evidence-based guidelines for computed tomography diagnosis of UIP. Two cardiothoracic ...[more]

PMID: 25551822

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Project description:BACKGROUND:Reliably abstracting outcomes from free-text electronic health records remains a challenge. While automated classification of free text has been a popular medical informatics topic, performance validation using real-world clinical data has been limited. The two main approaches are linguistic (natural language processing [NLP]) and statistical (machine learning). The authors have developed a hybrid system for abstracting computed tomography (CT) reports for specified outcomes. OBJECTIVES:The objective was to measure performance of a hybrid NLP and machine learning system for automated outcome classification of emergency department (ED) CT imaging reports. The hypothesis was that such a system is comparable to medical personnel doing the data abstraction. METHODS:A secondary analysis was performed on a prior diagnostic imaging study on 3,710 blunt facial trauma victims. Staff radiologists dictated CT reports as free text, which were then deidentified. A trained data abstractor manually coded the reference standard outcome of acute orbital fracture, with a random subset double-coded for reliability. The data set was randomly split evenly into training and testing sets. Training patient reports were used as input to the Medical Language Extraction and Encoding (MedLEE) NLP tool to create structured output containing standardized medical terms and modifiers for certainty and temporal status. Findings were filtered for low certainty and past/future modifiers and then combined with the manual reference standard to generate decision tree classifiers using data mining tools Waikato Environment for Knowledge Analysis (WEKA) 3.7.5 and Salford Predictive Miner 6.6. Performance of decision tree classifiers was evaluated on the testing set with or without NLP processing. RESULTS:The performance of machine learning alone was comparable to prior NLP studies (sensitivity = 0.92, specificity = 0.93, precision = 0.95, recall = 0.93, f-score = 0.94), and the combined use of NLP and machine learning showed further improvement (sensitivity = 0.93, specificity = 0.97, precision = 0.97, recall = 0.96, f-score = 0.97). This performance is similar to, or better than, that of medical personnel in previous studies. CONCLUSIONS:A hybrid NLP and machine learning automated classification system shows promise in coding free-text electronic clinical data.

Project description:BackgroundUsual interstitial pneumonia (UIP) is a pattern of interstitial pneumonia that is caused by different etiologies. This study aimed to investigate the transplant-free survival (TFS) and the decline in forced vital capacity (FVC) of the patients with UIP and probable UIP patterns on CT caused by various underlying conditions.MethodsA retrospective cohort study was conducted, enrolling patients with interstitial lung disease exhibiting a CT pattern consistent with UIP or probable UIP. Clinical and prognostic data of patients categorized by the etiology were compared.ResultsA total of 591 patients were included and classified into the following groups: idiopathic pulmonary fibrosis (IPF) (n = 320), connective tissue disease (CTD)-UIP (n = 229), asbestosis-UIP (n = 28), and hypersensitivity pneumonitis (HP)-UIP (n = 14). Advanced age, elevated levels of serum cytokeratin fraction 21-1 and percentage of neutrophils in bronchoalveolar lavage were observed in all groups. IPF patients showed a more rapid decline in FVC (133.9 mL/year) compared to CTD-UIP (24.5 mL/year, p = 0.001) and asbestosis-UIP (61.0 mL/year, p = 0.008) respectively. Sub-analysis of CTD-UIP revealed that patients with rheumatoid arthritis (RA)-UIP (88.1 mL/year) or antineutrophil cytoplasmic antibody-associated vasculitis (AAV)-UIP (72.9 mL/year) experienced a faster deterioration in FVC compared to those with primary Sjögren's syndrome (pSS)-UIP (25.9 mL/year, p < 0.05). Kaplan-Meier curves showed that IPF had the poorest TFS (median 55.9 months), followed by HP-UIP (57.5 months), CTD-UIP (66.7 months), and asbestosis-UIP (TFS not reached). RA-UIP or AAV-UIP did not exhibit any prognostic advantages compared to IPF, while asbestosis-UIP and pSS-UIP showed better survival rates.ConclusionPatients with UIP caused by different underlying conditions share certain common features, but the trajectories of disease progression and survival outcomes differ.

Project description:BackgroundMultimodality positron emission tomography/computed tomography (PET/CT) imaging combines the anatomical information of CT with the functional information of PET. In the diagnosis and treatment of many cancers, such as non-small cell lung cancer (NSCLC), PET/CT imaging allows more accurate delineation of tumor or involved lymph nodes for radiation planning.PurposeIn this paper, we propose a hybrid regional network method of automatically segmenting lung tumors from PET/CT images.MethodsThe hybrid regional network architecture synthesizes the functional and anatomical information from the two image modalities, whereas the mask regional convolutional neural network (R-CNN) and scoring fine-tune the regional location and quality of the output segmentation. This model consists of five major subnetworks, that is, a dual feature representation network (DFRN), a regional proposal network (RPN), a specific tumor-wise R-CNN, a mask-Net, and a score head. Given a PET/CT image as inputs, the DFRN extracts feature maps from the PET and CT images. Then, the RPN and R-CNN work together to localize lung tumors and reduce the image size and feature map size by removing irrelevant regions. The mask-Net is used to segment tumor within a volume-of-interest (VOI) with a score head evaluating the segmentation performed by the mask-Net. Finally, the segmented tumor within the VOI was mapped back to the volumetric coordinate system based on the location information derived via the RPN and R-CNN. We trained, validated, and tested the proposed neural network using 100 PET/CT images of patients with NSCLC. A fivefold cross-validation study was performed. The segmentation was evaluated with two indicators: (1) multiple metrics, including the Dice similarity coefficient, Jacard, 95th percentile Hausdorff distance, mean surface distance (MSD), residual mean square distance, and center-of-mass distance; (2) Bland-Altman analysis and volumetric Pearson correlation analysis.ResultsIn fivefold cross-validation, this method achieved Dice and MSD of 0.84 ± 0.15 and 1.38 ± 2.2 mm, respectively. A new PET/CT can be segmented in 1 s by this model. External validation on The Cancer Imaging Archive dataset (63 PET/CT images) indicates that the proposed model has superior performance compared to other methods.ConclusionThe proposed method shows great promise to automatically delineate NSCLC tumors on PET/CT images, thereby allowing for a more streamlined clinical workflow that is faster and reduces physician effort.

Project description:PURPOSE:To conduct a meta-analysis to determine specific computed tomography (CT) patterns and clinical features that discriminate between nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP). MATERIALS AND METHODS:The PubMed/Medline and Embase databases were searched for studies describing the radiological patterns of UIP and NSIP in chest CT images. Only studies involving histologically confirmed diagnoses and a consensus diagnosis by an interstitial lung disease (ILD) board were included in this analysis. The radiological patterns and patient demographics were extracted from suitable articles. We used random-effects meta-analysis by DerSimonian & Laird and calculated pooled odds ratios for binary data and pooled mean differences for continuous data. RESULTS:Of the 794 search results, 33 articles describing 2,318 patients met the inclusion criteria. Twelve of these studies included both NSIP (338 patients) and UIP (447 patients). NSIP-patients were significantly younger (NSIP: median age 54.8 years, UIP: 59.7 years; mean difference (MD) -4.4; p = 0.001; 95% CI: -6.97 to -1.77), less often male (NSIP: median 52.8%, UIP: 73.6%; pooled odds ratio (OR) 0.32; p<0.001; 95% CI: 0.17 to 0.60), and less often smokers (NSIP: median 55.1%, UIP: 73.9%; OR 0.42; p = 0.005; 95% CI: 0.23 to 0.77) than patients with UIP. The CT findings from patients with NSIP revealed significantly lower levels of the honeycombing pattern (NSIP: median 28.9%, UIP: 73.4%; OR 0.07; p<0.001; 95% CI: 0.02 to 0.30) with less peripheral predominance (NSIP: median 41.8%, UIP: 83.3%; OR 0.21; p<0.001; 95% CI: 0.11 to 0.38) and more subpleural sparing (NSIP: median 40.7%, UIP: 4.3%; OR 16.3; p = 0.005; 95% CI: 2.28 to 117). CONCLUSION:Honeycombing with a peripheral predominance was significantly associated with a diagnosis of UIP. The NSIP pattern showed more subpleural sparing. The UIP pattern was predominantly observed in elderly males with a history of smoking, whereas NSIP occurred in a younger patient population.

Dataset Information

Automated classification of usual interstitial pneumonia using regional volumetric texture analysis in high-resolution computed tomography.

Publications

Automated classification of usual interstitial pneumonia using regional volumetric texture analysis in high-resolution computed tomography.

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