Ontology highlight
ABSTRACT:
SUBMITTER: Lecona E
PROVIDER: S-EPMC4355532 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Lecona Emilio E Narendra Varun V Reinberg Danny D
Molecular and cellular biology 20150120 7
USP7 is a protein deubiquitinase with an essential role in development. Here, we provide evidence that USP7 regulates the activity of Polycomb repressive complex 1 (PRC1) in coordination with SCML2. There are six versions of PRC1 defined by the association of one of the PCGF homologues (PCGF1 to PCGF6) with the common catalytic subunit RING1B. First, we show that SCML2, a Polycomb group protein that associates with PRC1.2 (containing PCGF2/MEL18) and PRC1.4 (containing PCGF4/BMI1), modulates the ...[more]