Ontology highlight
ABSTRACT:
SUBMITTER: Milton ME
PROVIDER: S-EPMC4356312 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20150219 Pt 3
Infection by the parasite Plasmodium falciparum is the leading cause of malaria in humans. The parasite has a unique and essential plastid-like organelle called the apicoplast. The apicoplast contains a genome that undergoes replication and repair through the action of a replicative polymerase (apPOL). apPOL has no direct orthologs in mammalian polymerases and is therefore an attractive antimalarial drug target. No structural information exists for apPOL, and the Klenow fragment of Escherichia c ...[more]