Automating the application of smart materials for protein crystallization.
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ABSTRACT:
SUBMITTER: Khurshid S
PROVIDER: S-EPMC4356364 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Automating the application of smart materials for protein crystallization.
Khurshid Sahir S Govada Lata L El-Sharif Hazim F HF Reddy Subrayal M SM Chayen Naomi E NE
Acta crystallographica. Section D, Biological crystallography 20150226 Pt 3
The fabrication and validation of the first semi-liquid nonprotein nucleating agent to be administered automatically to crystallization trials is reported. This research builds upon prior demonstration of the suitability of molecularly imprinted polymers (MIPs; known as `smart materials') for inducing protein crystal growth. Modified MIPs of altered texture suitable for high-throughput trials are demonstrated to improve crystal quality and to increase the probability of success when screening fo ...[more]
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