Ontology highlight
ABSTRACT:
SUBMITTER: Deng Z
PROVIDER: S-EPMC4356630 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Deng Zhong Z Kim Eui Tae ET Vladimirova Olga O Dheekollu Jayaraju J Wang Zhuo Z Newhart Alyshia A Liu Dongmei D Myers Jaclyn L JL Hensley Scott E SE Moffat Jennifer J Janicki Susan M SM Fraser Nigel W NW Knipe David M DM Weitzman Matthew D MD Lieberman Paul M PM
Cell reports 20141211 6
Telomeres protect the ends of cellular chromosomes. We show here that infection with herpes simplex virus 1 (HSV-1) results in chromosomal structural aberrations at telomeres and the accumulation of telomere dysfunction-induced DNA damage foci (TIFs). At the molecular level, HSV-1 induces transcription of telomere repeat-containing RNA (TERRA), followed by the proteolytic degradation of the telomere protein TPP1 and loss of the telomere repeat DNA signal. The HSV-1-encoded E3 ubiquitin ligase IC ...[more]