Ontology highlight
ABSTRACT:
SUBMITTER: Andreassen OA
PROVIDER: S-EPMC4356743 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Andreassen O A OA Harbo H F HF Wang Y Y Thompson W K WK Schork A J AJ Mattingsdal M M Zuber V V Bettella F F Ripke S S Kelsoe J R JR Kendler K S KS O'Donovan M C MC Sklar P P McEvoy L K LK Desikan R S RS Lie B A BA Djurovic S S Dale A M AM
Molecular psychiatry 20140128 2
Converging evidence implicates immune abnormalities in schizophrenia (SCZ), and recent genome-wide association studies (GWAS) have identified immune-related single-nucleotide polymorphisms (SNPs) associated with SCZ. Using the conditional false discovery rate (FDR) approach, we evaluated pleiotropy in SNPs associated with SCZ (n=21,856) and multiple sclerosis (MS) (n=43,879), an inflammatory, demyelinating disease of the central nervous system. Because SCZ and bipolar disorder (BD) show substant ...[more]